Blood levels of angiotensin
نویسنده
چکیده
With the development of the technique of radioimmunoassay and its application to peptides of low molecular weight, measurement of the concentration of angiotensin I and I1 in blood has become possible. Numerous immunoassays for determining the circulating levels of the octapeptide angiotensin I1 have been developed in recent years (Boyd, Landon & Peart, 1967; Catt, Cain & Coghlan, 1967; Vallotton, Page & Haber, 1967; Goodfriend, Ball & Farley, 1968; Gocke, Gerten, Sherwood & Laragh, 1969; Sundsfjord, 1970; Dusterdieck & McElwee, 1971a). Radioimmunoassay of the decapeptide angiotensin I has also been used in in vitro systems for measurement of plasma renin activity (Boyd, Adamson, Fitz & Peart, 1969; Haber, Kverner, Page, Kliman & Purnode, 1969; Hollemans, van der Meer & Kloosterziel, 1969), and plasma renin concentration (Giese, Jorgensen, Nielsen, Lund & Munck, 1970). Although attempts have been made to estimate circulating levels of angiotensin I (Boyd, 1970; Page, 1970a; Cohen, Conn, Lucas, McDonald, Grim, Mayor, Saltman & Caldwell, 1972; Katz & Smith, 1972), these have been criticized on technical grounds (Boyd, 1970,1972; Page, 1970b; see also the Discussion section). The present paper describes a radioimmunoassay method for the measurement of angio-
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